Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.56 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.51 |
| ▸ | NOS2 | P35228 | 6/20 | 0.50 |
| ▸ | NOS1 | P29475 | 6/20 | 0.50 |
| ▸ | NOS3 | P29474 | 5/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ARG2 | P78540 | 4/20 | 0.44 |
| ▸ | ARG1 | P05089 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL29778163 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL2411547 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL30361345 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL288132 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL7928810 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL28759066 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL31663499 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL1790 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL6374054 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL29518651 | 1.00 | OTC (0.56) | OTCDDAH1NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 1002952 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436366-B1 | — | — | None | — | — | US | claimed |
| EP-1855694-B1 | ANTISENSE COMPOSITION FOR TREATING MUSCLE ATROPHY | SAREPTA THERAPEUTICS INC (US) | 2020-12-02 | — | — | EP | claimed |
| US-9976077-B2 | Photochromic articles containing polyoxometalate derivatives and methods of making same | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2018-05-22 | — | — | US | claimed |
| US-9976126-B2 | Modified glycine oxidase | AJINOMOTO CO., INC. (JP) | 2018-05-22 | — | — | US | claimed |
| US-9974851-B2 | Human rotavirus vaccine strains and diagnostics | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-05-22 | — | — | US | claimed |
| US-9974784-B2 | Inhibitors of activin-like receptor kinases | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2018-05-22 | — | — | US | claimed |
| US-9976184-B2 | Mutations in pancreatic neoplasms | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-05-22 | — | — | US | claimed |
| US-9974833-B2 | Methods of using compositions comprising variants and fusions of FGF19 polypeptides for modulating bile acid homeostasis in a subject having pregnancy intrahepatic cholestasis | NGM BIOPHARMACEUTICALS, INC. (US) | 2018-05-22 | — | — | US | claimed |
| US-9976076-B2 | Photochromic articles containing a polyoxometalate and methods of making same | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2018-05-22 | — | — | US | claimed |
| US-9976074-B2 | Self-suspending proppant particulates using canola protein-based hydrogel | HALLIBURTON ENERGY SERVICES, INC. (US) | 2018-05-22 | — | — | US | claimed |
| US-3988466-A | ANTIINFLAMMATORY, AMINO ACIDS | KYOWA HAKKO KOGYO CO., LTD. (JA) | 1976-10-26 | — | — | US | claimed |
| US-3984417-A | Method of producing active amino acid esters | AJINOMOTO CO., INC. (JA) | 1976-10-05 | — | — | US | claimed |
| US-3978035-A | POLYPEPTIDES | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DT) | 1976-08-31 | — | — | US | claimed |
| US-3971737-A | [2-Methyl-Ala6 ]LRH | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-07-27 | — | — | US | claimed |
| US-3953416-A | Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same | FOLKERS KARL | 1976-04-27 | — | — | US | claimed |
| US-3943241-A | Cariostatic composition | GENERAL MILLS, INC. (US) | 1976-03-09 | — | — | US | claimed |
| US-3941763-A | POLYPEPTIDE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-03-02 | — | — | US | claimed |
| US-3940380-A | P-Glu-D-Phe-Trp-Ser-Tyr-2-Me.Ala-Leu-Arg-Pro-NH2 and intermediates | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-02-24 | — | — | US | claimed |
| US-3933783-A | Formation of peptide bonds in the presence of isonitriles | AJINOMOTO CO., INC. (JA) | 1976-01-20 | — | — | US | claimed |
| US-3933782-A | (N-Acetyl)-Pro-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt and intermediates | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-01-20 | — | — | US | claimed |