Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.61 |
| ▸ | LCK | P06239 | 4/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.61 |
| ▸ | JAK3 | P52333 | 3/20 | 0.61 |
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 2/20 | 0.56 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | IDH2 | P48735 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
| ▸ | CTSC | P53634 | 2/20 | 0.52 |
| ▸ | BMX | P51813 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17915942 | 0.90 | IDH2 (0.64) | KDRLCKMAPK14JAK3EGFR | |
| SCHEMBL270255 | 0.90 | BTK (0.54) | KDRLCKMAPK14JAK3BTK | |
| SCHEMBL12320591 | 0.89 | EGFR (0.56) | KDRLCKMAPK14JAK3BTK | |
| SCHEMBL17916007 | 0.87 | BTK (0.69) | JAK3BTKEGFRITKSYK | |
| SCHEMBL17915951 | 0.84 | CTSC (0.56) | KDRLCKMAPK14JAK3EGFR | |
| SCHEMBL17915928 | 0.82 | BTK (0.65) | JAK3BTKEGFRITKSYK | |
| SCHEMBL265644 | 0.81 | BRD4 (0.75) | KDRLCKMAPK14JAK3TEK | |
| SCHEMBL14536376 | 0.81 | BRD4 (0.62) | KDRLCKMAPK14JAK3EGFR | |
| SCHEMBL270594 | 0.79 | CTSC (0.58) | IDH2CTSCSYK | |
| SCHEMBL301912 | 0.78 | CTSC (0.57) | BTKITKIDH2CTSCSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951684-B1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN INC (US) | 2016-07-13 | — | — | EP | disclosed |