Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.66 |
| ▸ | JAK2 | O60674 | 8/20 | 0.66 |
| ▸ | JAK1 | P23458 | 7/20 | 0.66 |
| ▸ | JAK3 | P52333 | 5/20 | 0.66 |
| ▸ | FLT3 | P36888 | 4/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.66 |
| ▸ | WEE1 | P30291 | 2/20 | 0.66 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.66 |
| ▸ | BUB1B | O60566 | 1/20 | 0.66 |
| ▸ | BRD2 | P25440 | 1/20 | 0.66 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.62 |
| ▸ | TYK2 | P29597 | 3/20 | 0.61 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | STK25 | O00506 | 1/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25382998 | 0.93 | BRD4 (0.74) | BRD4JAK2JAK1JAK3FLT3 | |
| SCHEMBL30565206 | 0.93 | BRD4 (0.74) | BRD4JAK2JAK1JAK3FLT3 | |
| SCHEMBL30565204 | 0.93 | BRD4 (0.74) | BRD4JAK2JAK1JAK3FLT3 | |
| SCHEMBL270232 | 0.91 | BRD4 (0.66) | BRD4JAK2JAK1JAK3FLT3 | |
| SCHEMBL13031088 | 0.90 | BRD4 (0.73) | BRD4JAK2JAK1JAK3FLT3 | |
| SCHEMBL12279008 | 0.89 | TNNI3K (0.57) | BRD4JAK2JAK1JAK3FLT3 | |
| SCHEMBL10267408 | 0.88 | BRD4 (0.64) | BRD4JAK2JAK1JAK3FLT3 | |
| SCHEMBL13031046 | 0.88 | BRD4 (0.74) | BRD4JAK2JAK1JAK3FLT3 | |
| SCHEMBL13031073 | 0.87 | BRD4 (0.67) | BRD4JAK2JAK1JAK3FLT3 | |
| SCHEMBL13031062 | 0.86 | BRD4 (0.71) | BRD4JAK2JAK1JAK3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951684-B1 | BI-ARYL META-PYRIMIDINE INHIBITORS OF KINASES | TARGEGEN INC (US) | 2016-07-13 | — | — | EP | disclosed |