Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 13/20 | 0.49 |
| ▸ | JAK3 | P52333 | 7/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19675 | 0.85 | JAK2 (0.53) | JAK2PTK2JAK3FYNPIK3CD | |
| SCHEMBL20773 | 0.78 | JAK2 (0.53) | JAK2PTK2JAK3FYNPIK3CD | |
| SCHEMBL21450 | 0.75 | JAK2 (0.52) | JAK2PTK2JAK3FYNPIK3CA | |
| SCHEMBL20311 | 0.74 | JAK2 (0.51) | JAK2PTK2JAK3 | |
| SCHEMBL20556 | 0.74 | JAK2 (0.50) | JAK2PTK2JAK3FYN | |
| SCHEMBL24046 | 0.73 | JAK2 (0.55) | JAK2PTK2JAK3FYNPIK3CD | |
| SCHEMBL22320 | 0.73 | FYN (0.56) | JAK2PTK2JAK3FYNPIK3CD | |
| SCHEMBL21119 | 0.73 | JAK2 (0.52) | JAK2PTK2JAK3 | |
| SCHEMBL22473 | 0.72 | JAK2 (0.49) | JAK2PTK2JAK3FYNPIK3CD | |
| SCHEMBL30618 | 0.72 | JAK2 (0.52) | JAK2PTK2JAK3PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609098-B1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-07-13 | — | — | EP | disclosed |