Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 16/20 | 0.67 |
| ▸ | FGFR4 | P22455 | 11/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19507760 | 0.92 | FGFR1 (0.66) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL17931861 | 0.90 | FGFR1 (0.77) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL17931856 | 0.89 | FGFR1 (0.67) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL19508316 | 0.89 | FGFR1 (0.67) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL19507379 | 0.87 | FGFR1 (0.66) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL19508207 | 0.86 | FGFR1 (0.71) | FGFR1FGFR4FGFR2FGFR3JAK3 | |
| SCHEMBL19508317 | 0.85 | FGFR1 (0.62) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL19508310 | 0.85 | FGFR1 (0.68) | FGFR1FGFR4FGFR2FGFR3JAK3 | |
| SCHEMBL19470191 | 0.85 | FGFR1 (0.76) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL19508044 | 0.84 | FGFR1 (0.66) | FGFR1FGFR4FGFR2FGFR3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016115412-A1 | DUAL-WARHEAD COVALENT INHIBITORS OF FGFR-4 | NEWAVE PHARMACEUTICAL LLC (US) | 2016-07-21 | — | — | WO | disclosed |