Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1793305 | 0.83 | CHRNA7 (0.47) | HTR6NPC1RAB9AEEDTP53 | |
| SCHEMBL930239 | 0.81 | CHRNA7 (0.41) | NPC1RAB9ACHRNA7 | |
| SCHEMBL930768 | 0.73 | CHRNA7 (0.59) | NPC1CHRNA7 | |
| SCHEMBL928081 | 0.71 | MAPT (0.42) | TP53LMNA | |
| SCHEMBL928387 | 0.70 | CHRNA7 (0.42) | NPC1RAB9ACHRNA7 | |
| SCHEMBL928096 | 0.69 | MAPT (0.40) | TP53LMNA | |
| Bromide SCHEMBL928348 | 0.69 | CHRNA7 (0.41) | NPC1RAB9ACHRNA7 | |
| SCHEMBL6323965 | 0.69 | CHRNA7 (0.42) | NPC1RAB9ACHRNA7 | |
| Bromide SCHEMBL928337 | 0.68 | CHRNA7 (0.41) | NPC1RAB9ACHRNA7 | |
| SCHEMBL928323 | 0.68 | NPC1 (0.45) | NPC1RAB9ATP53CHRNA7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316836-A1 | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors | Abbott Laboratories (US) | 2011-05-04 | — | — | EP | disclosed |