Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TLR2 | O60603 | 2/20 | 0.45 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18725627 | 1.00 | KMT2A (0.55) | KMT2ATLR2TLR1MDM2CASP3 | |
| SCHEMBL21461837 | 0.91 | KMT2A (0.55) | KMT2ATLR2TLR1MDM2CASP3 | |
| SCHEMBL30983384 | 0.90 | KMT2A (0.60) | KMT2ATLR2TLR1MDM2CASP3 | |
| SCHEMBL17130698 | 0.90 | SYK (0.49) | KMT2ATLR2TLR1MDM2SYK | |
| SCHEMBL18826572 | 0.90 | KMT2A (0.48) | KMT2ATLR2TLR1MDM2CASP3 | |
| SCHEMBL4600617 | 0.89 | KMT2A (0.56) | KMT2ATLR2TLR1MDM2CASP3 | |
| SCHEMBL29483213 | 0.89 | KMT2A (0.56) | KMT2ATLR2TLR1MDM2CASP3 | |
| SCHEMBL4600619 | 0.89 | KMT2A (0.56) | KMT2ATLR2TLR1MDM2CASP3 | |
| SCHEMBL29397881 | 0.89 | KMT2A (0.56) | KMT2ATLR2TLR1MDM2CASP3 | |
| SCHEMBL22151447 | 0.88 | KMT2A (0.43) | KMT2ATLR2TLR1MDM2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170232055-A1 | METHODS OF SYNTHESIZING GAMMA-AAPEPTIDES, GAMMA-AAPEPTIDE BUILDING BLOCKS, GAMMA-AAPEPTIDE LIBRARIES, AND GAMMA-AAPEPTIDE INHIBITORS OF ALPHA-BETA40 AGGREGATES | UNIVERSITY OF SOUTH FLORIDA (US) | 2017-08-17 | — | — | US | disclosed |
| US-20160209422-A1 | METHODS OF SYNTHESIZING y-AAPEPTIDES, y-AAPEPTIDE BUILDING BLOCKS, y-AAPEPTIDE LIBRARIES, AND y-AAPEPTIDE INHIBITORS OF Ab40 AGGREGATES | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170232055-A1 | METHODS OF SYNTHESIZING GAMMA-AAPEPTIDES, GAMMA-AAPEPTIDE BUILDING BLOCKS, GAMMA-AAPEPTIDE LIBRARIES, AND GAMMA-AAPEPTIDE INHIBITORS OF ALPHA-BETA40 AGGREGATES | APP, APBA1, IAPP | KMT2A 2836/4885TLR2 4740/4885TLR1 4774/4885 |
| US-20160209422-A1 | METHODS OF SYNTHESIZING y-AAPEPTIDES, y-AAPEPTIDE BUILDING BLOCKS, y-AAPEPTIDE LIBRARIES, AND y-AAPEPTIDE INHIBITORS OF Ab40 AGGREGATES | APBA1, APP, IAPP | KMT2A 2287/4885TLR2 4670/4885TLR1 4726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.