Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 12/20 | 0.74 |
| ▸ | MMEL1 | Q495T6 | 8/20 | 0.74 |
| ▸ | ACE | P12821 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18672666 | 1.00 | MME (0.74) | MMEMMEL1ACE | |
| SCHEMBL12317264 | 1.00 | MME (0.74) | MMEMMEL1ACE | |
| SCHEMBL18672524 | 0.93 | MME (0.76) | MMEMMEL1ACE | |
| SCHEMBL17937520 | 0.93 | MME (0.76) | MMEMMEL1ACE | |
| SCHEMBL12317263 | 0.93 | MME (0.76) | MMEMMEL1ACE | |
| SCHEMBL12317282 | 0.90 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL18672614 | 0.90 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL17667987 | 0.90 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL12803905 | 0.89 | MME (0.60) | MMEMMEL1ACE | |
| SCHEMBL18672540 | 0.89 | MME (0.60) | MMEMMEL1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3048100-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | Novartis AG (CH) | 2016-07-27 | — | — | EP | disclosed |