Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.69 |
| ▸ | MMEL1 | Q495T6 | 7/20 | 0.61 |
| ▸ | ACE | P12821 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12317464 | 1.00 | MME (0.69) | MMEMMEL1ACE | |
| SCHEMBL17937516 | 0.94 | MME (0.68) | MMEMMEL1ACE | |
| SCHEMBL12317435 | 0.94 | MME (0.68) | MMEMMEL1ACE | |
| SCHEMBL12317311 | 0.91 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL17937513 | 0.91 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL18672732 | 0.91 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL17937545 | 0.87 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL12317460 | 0.87 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL17937534 | 0.87 | MME (0.70) | MMEMMEL1ACE | |
| SCHEMBL12317445 | 0.87 | MME (0.70) | MMEMMEL1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9603819-B2 | Substituted aminobutyric derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2017-03-28 | — | — | US | disclosed |
| EP-3048100-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | Novartis AG (CH) | 2016-07-27 | — | — | EP | disclosed |