Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.50 |
| ▸ | SGK1 | O00141 | 4/20 | 0.45 |
| ▸ | AXL | P30530 | 6/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.44 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | FES | P07332 | 2/20 | 0.43 |
| ▸ | ROS1 | P08922 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.43 |
| ▸ | FER | P16591 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17939012 | 1.00 | JAK3 (0.50) | JAK3SGK1AXLCAMKK2PLCG1 | |
| SCHEMBL17939567 | 1.00 | JAK3 (0.50) | JAK3SGK1AXLCAMKK2PLCG1 | |
| SCHEMBL17939384 | 0.95 | JAK3 (0.46) | JAK3SGK1AXLCAMKK2PLCG1 | |
| SCHEMBL17939031 | 0.95 | JAK3 (0.46) | JAK3SGK1AXLCAMKK2PLCG1 | |
| SCHEMBL17939028 | 0.95 | JAK3 (0.46) | JAK3SGK1AXLCAMKK2PLCG1 | |
| SCHEMBL17938935 | 0.95 | JAK3 (0.48) | JAK3SGK1AXLCAMKK2PLCG1 | |
| SCHEMBL17938957 | 0.93 | SGK1 (0.48) | JAK3SGK1AXLCAMKK2PLCG1 | |
| SCHEMBL17939731 | 0.92 | PLCG1 (0.49) | JAK3PLCG1NEK1DYRK1AEGFR | |
| SCHEMBL17939584 | 0.92 | PLCG1 (0.49) | JAK3PLCG1NEK1DYRK1AEGFR | |
| SCHEMBL17939582 | 0.92 | PLCG1 (0.49) | JAK3PLCG1NEK1DYRK1AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190106439-A1 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | CONFLUENCE LIFE SCIENCES, INC. | 2019-04-11 | — | — | US | disclosed |
| US-10150783-B2 | Heterocyclic ITK inhibitors for treating inflammation and cancer | ACLARIS THERAPEUTICS, INC. (US) | 2018-12-11 | — | — | US | disclosed |
| US-20170260211-A1 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | ACLARIS THERAPEUTICS, INC. | 2017-09-14 | — | — | US | disclosed |
| US-9695200-B2 | Heterocyclic ITK inhibitors for treating inflammation and cancer | CONFLUENCE LIFE SCIENCES, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695200-B2 | Heterocyclic ITK inhibitors for treating inflammation and cancer | CONFLUENCE LIFE SCIENCES, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20160213653-A1 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | ACLARIS THERAPEUTICS, INC. | 2016-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106439-A1 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | ITK, NFKBIA, TNNI3K | JAK3 1704/4885SGK1 658/4885AXL 3309/4885 |
| US-20170260211-A1 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | ITK, NFKBIA, TNNI3K | JAK3 1704/4885SGK1 658/4885AXL 3309/4885 |
| US-20160213653-A1 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | ITK, NFKBIA, TNNI3K | JAK3 1704/4885SGK1 658/4885AXL 3309/4885 |
| US-10150783-B2 | Heterocyclic ITK inhibitors for treating inflammation and cancer | ITK, NFKBIA, TNNI3K | JAK3 1704/4885SGK1 658/4885AXL 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.