Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 20/20 | 1.00 |
| ▸ | PSEN2 | P49810 | 20/20 | 1.00 |
| ▸ | APH1B | Q8WW43 | 20/20 | 1.00 |
| ▸ | NCSTN | Q92542 | 20/20 | 1.00 |
| ▸ | APH1A | Q96BI3 | 20/20 | 1.00 |
| ▸ | PSENEN | Q9NZ42 | 20/20 | 1.00 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nirogacestat SCHEMBL13184912 | 0.95 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL19422226 | 0.95 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL29388600 | 0.95 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL13184754 | 0.95 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL1796299 | 0.95 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL26374374 | 0.95 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL26374369 | 0.95 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL29658278 | 0.95 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL21050500 | 0.95 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nirogacestat SCHEMBL31142148 | 0.94 | PSEN1 (0.99) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730119-B1 | IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-06-25 | — | — | EP | claimed |
| US-7951958-B2 | Imidazole compounds for the treatment of neurodegenerative disorders | PFIZER INC. (US) | 2011-05-31 | — | — | US | disclosed |