Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796312 | 0.85 | GRM5 (0.55) | GRM5NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL7905661 | 0.85 | NPC1 (0.59) | GRM5NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL7897356 | 0.81 | GRM5 (0.51) | GRM5NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL7904711 | 0.81 | GRM5 (0.51) | GRM5NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13148025 | 0.81 | GRM5 (0.51) | GRM5NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1792287 | 0.81 | NPC1 (0.54) | GRM5NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1797965 | 0.80 | GRM5 (0.51) | GRM5NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1794034 | 0.79 | GRM5 (0.49) | GRM5NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1794198 | 0.79 | GRM5 (0.49) | GRM5NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1796214 | 0.79 | GRM5 (0.49) | GRM5NPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-1987003-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093542-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | disclosed |