Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.82 |
| ▸ | FLT3 | P36888 | 2/20 | 0.78 |
| ▸ | KIT | P10721 | 1/20 | 0.78 |
| ▸ | EGFR | P00533 | 4/20 | 0.74 |
| ▸ | TEC | P42680 | 3/20 | 0.74 |
| ▸ | BMX | P51813 | 3/20 | 0.74 |
| ▸ | ITK | Q08881 | 3/20 | 0.74 |
| ▸ | TXK | P42681 | 2/20 | 0.74 |
| ▸ | LYN | P07948 | 2/20 | 0.74 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.74 |
| ▸ | BLK | P51451 | 2/20 | 0.74 |
| ▸ | LCK | P06239 | 2/20 | 0.74 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.74 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.74 |
| ▸ | LATS1 | O95835 | 1/20 | 0.74 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.74 |
| ▸ | FYN | P06241 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17951872 | 0.95 | BTK (0.78) | BTKFLT3KITEGFRTEC | |
| SCHEMBL17951884 | 0.93 | BTK (0.89) | BTKFLT3KITEGFRTEC | |
| SCHEMBL3363036 | 0.92 | BTK (0.85) | BTKFLT3KITEGFRTEC | |
| SCHEMBL22625356 | 0.92 | BTK (0.85) | BTKFLT3KITEGFRTEC | |
| SCHEMBL20204786 | 0.92 | BTK (0.85) | BTKFLT3KITEGFRTEC | |
| SCHEMBL31615786 | 0.92 | BTK (0.85) | BTKFLT3KITEGFRTEC | |
| SCHEMBL19649286 | 0.91 | BTK (0.84) | BTKFLT3KITEGFRTEC | |
| SCHEMBL1613909 | 0.91 | BTK (0.88) | BTKFLT3KITEGFRTEC | |
| SCHEMBL22625353 | 0.91 | BTK (0.84) | BTKFLT3KITEGFRTEC | |
| SCHEMBL17951807 | 0.91 | BTK (0.84) | BTKFLT3KITEGFRTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3248979-B1 | NOVEL INHIBITOR OF FLT3 KINASE AND USE THEREOF | HEFEI INST PHYSICAL SCI CAS (CN) | 2021-04-14 | — | — | EP | disclosed |
| EP-3248979-A1 | NOVEL INHIBITOR OF FLT3 KINASE AND USE THEREOF | Hefei Institutes of Physical Sicence, Chinese Academy of Sciences (CN) | 2017-11-29 | — | — | EP | disclosed |
| WO-2016115869-A1 | NOVEL INHIBITOR OF FLT3 KINASE AND USE THEREOF | 中国科学院合肥物质科学研究院 | 2016-07-28 | — | — | WO | disclosed |