Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17951906 | 0.90 | AXL (0.53) | NTRK1MAPK1AXLCDK8TNIK | |
| SCHEMBL19068203 | 0.81 | NTRK1 (0.54) | NTRK1PIK3CASLC2A1PIK3CGKIT | |
| SCHEMBL19068207 | 0.80 | NTRK1 (0.53) | NTRK1PIK3CASLC2A1PIK3CGKIT | |
| SCHEMBL17951910 | 0.79 | NTRK1 (0.47) | NTRK1PIK3CASLC2A1PIK3CGMAPK1 | |
| SCHEMBL17939055 | 0.78 | JAK3 (0.47) | NTRK1PIK3CANEK1MAPK1 | |
| SCHEMBL31235685 | 0.78 | MAPK1 (0.59) | NTRK1PIK3CAMAPK1 | |
| SCHEMBL17938932 | 0.78 | NTRK1 (0.47) | NTRK1PIK3CASLC2A1PIK3CGKIT | |
| SCHEMBL17939239 | 0.76 | JAK3 (0.46) | NTRK1PIK3CASLC2A1PIK3CGNEK1 | |
| SCHEMBL17939337 | 0.75 | NTRK1 (0.46) | NTRK1PIK3CASLC2A1PIK3CGMAPK1 | |
| SCHEMBL17939340 | 0.75 | NTRK1 (0.46) | NTRK1PIK3CASLC2A1PIK3CGMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016118951-A2 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-07-28 | — | — | WO | disclosed |