Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 16/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.61 |
| ▸ | GABRP | O00591 | 1/20 | 0.59 |
| ▸ | GABRD | O14764 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | KLK3 | P07288 | 1/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17954406 | 0.87 | AR (0.66) | ARHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL18815307 | 0.87 | ABCG2 (0.67) | ARHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL17954369 | 0.86 | AR (0.68) | ARHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL22642216 | 0.85 | AR (0.70) | ARHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26115570 | 0.84 | AR (0.69) | ARHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL27372922 | 0.83 | AR (0.80) | ARHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL17519961 | 0.83 | AR (0.72) | ARHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL15506471 | 0.83 | ABCG2 (0.68) | ARHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL31476803 | 0.83 | AR (0.67) | ARHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL17947407 | 0.82 | ABCG2 (0.62) | ARHDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016118666-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2016-07-28 | — | — | WO | disclosed |