Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.54 |
| ▸ | PI4KA | P42356 | 5/20 | 0.54 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.54 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.54 |
| ▸ | XDH | P47989 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15627374 | 1.00 | PI4KB (0.54) | PI4KBPI4KAPI4K2BPI4K2AXDH | |
| SCHEMBL23059282 | 1.00 | PI4KB (0.54) | PI4KBPI4KAPI4K2BPI4K2AXDH | |
| SCHEMBL12206789 | 0.83 | PI4KB (0.61) | PI4KBPI4KAPI4K2BPI4K2AXDH | |
| SCHEMBL243654 | 0.78 | PI4KB (0.54) | PI4KBPI4KAPI4K2BPI4K2AXDH | |
| SCHEMBL23059283 | 0.77 | ADORA2A (0.33) | PI4KBPI4KAPI4K2BPI4K2AXDH | |
| SCHEMBL23059277 | 0.77 | ADORA2A (0.33) | PI4KBPI4KAPI4K2BPI4K2AXDH | |
| SCHEMBL23059275 | 0.77 | ADORA2A (0.33) | PI4KBPI4KAPI4K2BPI4K2AXDH | |
| SCHEMBL29773082 | 0.73 | PI4KA (0.61) | PI4KBPI4KAPI4K2BPI4K2AXDH | |
| SCHEMBL156688 | 0.73 | PI4KA (0.61) | PI4KBPI4KAPI4K2BPI4K2AXDH | |
| SCHEMBL23059276 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210060022-A1 | TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS | INFINITY PHARMACEUTICALS, INC. | 2021-03-04 | — | — | US | disclosed |
| US-20120059000-A1 | CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION | INFINITY PHARMACEUTICALS, INC. | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059000-A1 | CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION | MAP3K13, AKT3, PIK3CA | PI4KB 44/4885PI4KA 35/4885PI4K2B 83/4885 |
| US-20210060022-A1 | TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS | PIK3CA, MCL1, PIK3CB | PI4KB 8/4885PI4KA 4/4885PI4K2B 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.