Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 6/20 | 0.43 |
| ▸ | REN | P00797 | 4/20 | 0.43 |
| ▸ | PEPD | P12955 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270677 | 0.88 | HSD17B10 (0.42) | HSD17B10ACERENPEPDKDM4E | |
| SCHEMBL7323258 | 0.88 | DPP4 (0.50) | HSD17B10ACERENPEPDKDM4E | |
| SCHEMBL10768669 | 0.88 | HSD17B10 (0.42) | HSD17B10ACERENPEPDKDM4E | |
| SCHEMBL30406562 | 0.87 | KLK5 (0.46) | HSD17B10ACEPEPDXPNPEP1POLB | |
| SCHEMBL7206198 | 0.85 | DPP4 (0.52) | HSD17B10ACERENPEPDKDM4E | |
| Oxalic Acid SCHEMBL10872013 | 0.85 | DPP4 (0.48) | HSD17B10ACERENPEPDKDM4E | |
| SCHEMBL15223614 | 0.85 | ACE (0.49) | HSD17B10ACERENPEPDKDM4E | |
| SCHEMBL7281828 | 0.85 | HSD17B10 (0.40) | HSD17B10ACERENPEPDKDM4E | |
| SCHEMBL21021650 | 0.85 | HSD17B10 (0.40) | HSD17B10ACERENPEPDKDM4E | |
| SCHEMBL10558726 | 0.84 | PEPD (0.41) | HSD17B10ACERENPEPDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403782-B2 | Fused heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2016-08-02 | — | — | US | disclosed |