Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.55 |
| ▸ | EED | O75530 | 3/20 | 0.49 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.49 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.49 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.49 |
| ▸ | EZH1 | Q92800 | 6/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595121 | 0.93 | EZH2 (0.63) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL12180087 | 0.90 | EZH2 (0.62) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL14717700 | 0.90 | EZH2 (0.62) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL12180130 | 0.83 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL17956109 | 0.83 | EZH2 (0.49) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL2594805 | 0.80 | EZH2 (0.65) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL12180104 | 0.80 | EZH2 (0.53) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL2594868 | 0.80 | EZH2 (0.76) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL2594829 | 0.79 | EZH2 (0.67) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL2595098 | 0.78 | EZH2 (0.66) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773754-B1 | Compounds for use in the treatment of T-cell mediated diseases | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2016-08-03 | — | — | EP | claimed |