SCHEMBL1796356

SCHEMBL1796356

Cc1ccc(-c2ccc(N3CC4CN(C)C4C3)nn2)cc1

nearest known ligand 0.71

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 7/20 0.56
HTR3A P46098 1/20 0.56
CHRNB4 P30926 1/20 0.56
CHRNA3 P32297 1/20 0.56
HRH3 Q9Y5N1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL927426 1.00 CHRNA7 (0.56) CHRNA7HTR3ACHRNB4CHRNA3HRH3
SCHEMBL928809 0.88 CHRNA7 (0.54) CHRNA7HTR3ACHRNB4CHRNA3HRH3
SCHEMBL928732 0.88 CHRNA7 (0.54) CHRNA7HTR3ACHRNB4CHRNA3HRH3
SCHEMBL1791883 0.88 CHRNA7 (0.54) CHRNA7HTR3ACHRNB4CHRNA3HRH3
SCHEMBL5397144 0.88 CHRNA7 (0.72) CHRNA7HTR3ACHRNB4CHRNA3
SCHEMBL928536 0.88 CHRNA7 (0.72) CHRNA7HTR3ACHRNB4CHRNA3
SCHEMBL930220 0.88 CHRNA7 (0.72) CHRNA7HTR3ACHRNB4CHRNA3
SCHEMBL930430 0.85 CHRNA7 (0.76) CHRNA7HTR3ACHRNB4CHRNA3
SCHEMBL1791742 0.84 MAPT (0.46) CHRNA7HTR3ACHRNB4CHRNA3
Hydrochloric Acid SCHEMBL1794321 0.83 CHRNA7 (0.74) CHRNA7HTR3ACHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2316836-A1 Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors Abbott Laboratories (US) 2011-05-04 EP claimed
JP-2007521323-A 2007-08-02 JP claimed
EP-1664045-A1 SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES AS LIGANDS AT ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTORS Abbott Laboratories (US) 2006-06-07 EP claimed
WO-2005028477-A1 SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES AS LIGANDS AT ALPHA 7 NICOTINIC ACETY LCHOLINE RECEPTORS ABBOTT LABORATORIES (US) 2005-03-31 WO claimed
EP-2316836-A1 Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors Abbott Laboratories (US) 2011-05-04 EP disclosed
EP-1664045-A1 SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES AS LIGANDS AT ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTORS Abbott Laboratories (US) 2006-06-07 EP disclosed
WO-2005028477-A1 SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES AS LIGANDS AT ALPHA 7 NICOTINIC ACETY LCHOLINE RECEPTORS ABBOTT LABORATORIES (US) 2005-03-31 WO disclosed