Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17964289 | 0.93 | TP53 (0.50) | TP53L3MBTL1BRD4MIFGAA | |
| SCHEMBL9509126 | 0.92 | BRD4 (0.44) | TP53L3MBTL1BRD4MIFGAA | |
| SCHEMBL10642355 | 0.85 | BRD4 (0.42) | TP53L3MBTL1BRD4MIFGAA | |
| SCHEMBL10637141 | 0.85 | BRD4 (0.42) | TP53L3MBTL1BRD4MIFGAA | |
| SCHEMBL10642729 | 0.84 | TP53 (0.56) | TP53L3MBTL1TSHRMAPTITGB3 | |
| SCHEMBL17964261 | 0.84 | MIF (0.38) | TP53L3MBTL1BRD4MIFGAA | |
| SCHEMBL10848706 | 0.82 | TSHR (0.40) | BRD4MIFGAATSHRMAPT | |
| SCHEMBL17964257 | 0.81 | BRD4 (0.41) | BRD4MIFGAAHDAC6 | |
| SCHEMBL19768599 | 0.81 | BRD4 (0.41) | BRD4MIFGAAHDAC6 | |
| SCHEMBL17964285 | 0.79 | TP53 (0.49) | TP53L3MBTL1TSHRMAPTITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250559-A1 | SPIROFURANONE COMPOUNDS, DERIVATIVES THEREOF AND PROCESSES FOR THEIR PREPARATION | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2017-12-06 | — | — | EP | disclosed |
| WO-2016120879-A1 | SPIROFURANONE COMPOUNDS, DERIVATIVES THEREOF AND PROCESSES FOR THEIR PREPARATION | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2016-08-04 | — | — | WO | disclosed |