Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 10/20 | 0.58 |
| ▸ | GCKR | Q14397 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518 | 0.85 | GCK (0.80) | GCKGCKRPOLBTDP1MAPT | |
| SCHEMBL17708 | 0.85 | GCK (0.80) | GCKGCKRPOLBTDP1MAPT | |
| SCHEMBL16950 | 0.85 | POLB (0.65) | GCKGCKRPOLBTDP1SMN1; SMN2 | |
| SCHEMBL17099 | 0.85 | GCK (0.80) | GCKGCKRPOLBTDP1MAPT | |
| SCHEMBL12078733 | 0.80 | GCKR (0.81) | GCKGCKRMEN1KMT2AMAPT | |
| SCHEMBL15854 | 0.80 | GCKR (0.81) | GCKGCKRMEN1KMT2AMAPT | |
| SCHEMBL33152 | 0.80 | GCKR (0.81) | GCKGCKRMEN1KMT2AMAPT | |
| SCHEMBL18023 | 0.76 | GCK (0.77) | GCKGCKRMEN1KMT2AHSD11B1 | |
| SCHEMBL15754 | 0.76 | GCK (0.77) | GCKGCKRMEN1KMT2AHSD11B1 | |
| SCHEMBL12079031 | 0.76 | GCK (0.77) | GCKGCKRMEN1KMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |