Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650971 | 0.91 | HDAC1 (0.73) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL650972 | 0.91 | HDAC1 (0.73) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL652176 | 0.85 | HDAC1 (0.75) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL652177 | 0.85 | HDAC1 (0.75) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL651089 | 0.82 | HDAC1 (0.75) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL652679 | 0.81 | HDAC1 (1.00) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL653795 | 0.81 | HDAC1 (1.00) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL652032 | 0.80 | HDAC1 (0.63) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL653890 | 0.80 | HDAC1 (0.63) | HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL1640951 | 0.79 | KCNH2 (0.89) | HDAC1KCNH2HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2023924-B1 | ARYL-FUSED SPIROCYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2016-08-03 | — | — | EP | disclosed |