Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.31 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498004 | 1.00 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CCYP3A4DDB1 | |
| SCHEMBL3373883 | 1.00 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CCYP3A4DDB1 | |
| SCHEMBL7880266 | 1.00 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CCYP3A4DDB1 | |
| SCHEMBL498005 | 1.00 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CCYP3A4DDB1 | |
| SCHEMBL3805806 | 1.00 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CCYP3A4DDB1 | |
| SCHEMBL3970772 | 1.00 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CCYP3A4DDB1 | |
| SCHEMBL8161544 | 1.00 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CCYP3A4DDB1 | |
| SCHEMBL13610303 | 1.00 | ADRB3 (0.44) | ADRB3ADRA2BADRA2CCYP3A4DDB1 | |
| SCHEMBL2288077 | 0.96 | ADRB3 (0.43) | ADRB3ADRA2BADRA2CCYP3A4DDB1 | |
| SCHEMBL2291426 | 0.96 | ADRB3 (0.43) | ADRB3ADRA2BADRA2CCYP3A4DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225249-B1 | PROCESS FOR THE PREPARATION OF A MACROCYCLE | HOFFMANN LA ROCHE (CH) | 2016-08-03 | — | — | EP | disclosed |