SCHEMBL17970197

SCHEMBL17970197

Bc1nc(-c2cccc(NC(=O)c3cc4c(s3)CCCC4)c2C)cn(C)c1=O

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BTK Q06187 20/20 0.77
CD69 Q07108 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11987750 0.91 BTK (0.77) BTKCD69
SCHEMBL1205247 0.90 BTK (0.75) BTKCD69
SCHEMBL1204154 0.90 BTK (0.74) BTKCD69
SCHEMBL13305728 0.87 BTK (1.00) BTKCD69
SCHEMBL1067205 0.85 BTK (0.88) BTKCD69
SCHEMBL1066510 0.83 BTK (1.00) BTKCD69
SCHEMBL12602970 0.83 BTK (0.70) BTKCD69
SCHEMBL12962331 0.82 BTK (0.74) BTKCD69
SCHEMBL1203898 0.81 BTK (0.69) BTKCD69
SCHEMBL1068415 0.81 BTK (0.89) BTKCD69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2188267-B1 SUBSTITUTED AMIDES, METHODS OF MAKING, USE THEREOF FOR THE TREATMENT OF DISEASES SUCH AS CANCER GILEAD CONNECTICUT INC (US) 2016-08-03 EP disclosed