Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 13/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.40 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3116829 | 0.90 | CSNK1E (0.53) | CSNK1ECSNK1DRIPK3HSD17B10PIM1 | |
| SCHEMBL3109345 | 0.88 | CSNK1E (0.51) | CSNK1ECSNK1DRIPK3HSD17B10MAPK13 | |
| SCHEMBL3124152 | 0.87 | CSNK1E (0.49) | CSNK1ECSNK1DRIPK3ROCK2ROCK1 | |
| SCHEMBL3119961 | 0.87 | CSNK1E (0.65) | CSNK1ECSNK1DRIPK3 | |
| SCHEMBL3359820 | 0.84 | CSNK1E (0.53) | CSNK1ECSNK1DRIPK3HSD17B10PIM1 | |
| SCHEMBL1394151 | 0.83 | CSNK1E (0.44) | CSNK1ECSNK1DROCK2ROCK1CDC42BPA | |
| SCHEMBL17976948 | 0.82 | CSNK1E (0.76) | CSNK1ECSNK1DRIPK3ADORA2AADORA2B | |
| SCHEMBL3104980 | 0.82 | CSNK1E (0.51) | CSNK1ERIPK3HSD17B10 | |
| SCHEMBL3113529 | 0.82 | CSNK1E (0.46) | CSNK1ERIPK3HSD17B10MAPK13MAPK12 | |
| SCHEMBL3115962 | 0.82 | CSNK1E (0.68) | CSNK1ECSNK1DRIPK3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170889-B1 | 6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2016-08-17 | — | — | EP | claimed |
| EP-2170889-B1 | 6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2016-08-17 | — | — | EP | disclosed |