⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027407 | 1.00 | — | — | |
| SCHEMBL6068338 | 1.00 | — | — | |
| SCHEMBL11315725 | 1.00 | — | — | |
| SCHEMBL1655264 | 1.00 | — | — | |
| SCHEMBL6282130 | 1.00 | — | — | |
| SCHEMBL1338748 | 0.97 | — | — | |
| SCHEMBL2385426 | 0.87 | — | — | |
| SCHEMBL2154219 | 0.83 | — | — | |
| SCHEMBL2155057 | 0.83 | — | — | |
| SCHEMBL2155118 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402358-A2 | 2',3'-Didehydro-3'-deoxy-4'-ethynylothymidine derivatives for treatment infections caused by human immunodeficiency virus (HIV) multidrug resistant strains, method of their synthesis and pharmaceutically acceptable forms of drugs | Instytut Biochemii I Biofizyki Pan (PL) | 2012-01-04 | — | — | EP | claimed |
| EP-2402356-A2 | Modified 2',3'-dideoxynucleosides for treatment infections caused by human immunodeficiency virus (HIV) multidrug resistant strains, method of their synthesis and the pharmaceutical agent containing these nucleosides | Instytut Biochemii I Biofizyki Pan (PL) | 2012-01-04 | — | — | EP | claimed |
| EP-2402358-A3 | 2',3'-Didehydro-3'-deoxy-4'-ethynylothymidine derivatives for treatment infections caused by human immunodeficiency virus (HIV) multidrug resistant strains, method of their synthesis and pharmaceutically acceptable forms of drugs | Instytut Biochemii I Biofizyki Pan (PL) | 2012-07-18 | — | — | EP | disclosed |
| EP-2402356-A3 | Modified 2',3'-dideoxynucleosides for treatment infections caused by human immunodeficiency virus (HIV) multidrug resistant strains, method of their synthesis and the pharmaceutical agent containing these nucleosides | Instytut Biochemii I Biofizyki Pan (PL) | 2012-07-18 | — | — | EP | disclosed |
| EP-2402358-A2 | 2',3'-Didehydro-3'-deoxy-4'-ethynylothymidine derivatives for treatment infections caused by human immunodeficiency virus (HIV) multidrug resistant strains, method of their synthesis and pharmaceutically acceptable forms of drugs | Instytut Biochemii I Biofizyki Pan (PL) | 2012-01-04 | — | — | EP | disclosed |
| EP-2402358-A2 | 2',3'-Didehydro-3'-deoxy-4'-ethynylothymidine derivatives for treatment infections caused by human immunodeficiency virus (HIV) multidrug resistant strains, method of their synthesis and pharmaceutically acceptable forms of drugs | Instytut Biochemii I Biofizyki Pan (PL) | 2012-01-04 | — | — | EP | disclosed |
| EP-2402356-A2 | Modified 2',3'-dideoxynucleosides for treatment infections caused by human immunodeficiency virus (HIV) multidrug resistant strains, method of their synthesis and the pharmaceutical agent containing these nucleosides | Instytut Biochemii I Biofizyki Pan (PL) | 2012-01-04 | — | — | EP | disclosed |
| EP-2402356-A2 | Modified 2',3'-dideoxynucleosides for treatment infections caused by human immunodeficiency virus (HIV) multidrug resistant strains, method of their synthesis and the pharmaceutical agent containing these nucleosides | Instytut Biochemii I Biofizyki Pan (PL) | 2012-01-04 | — | — | EP | disclosed |