Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.64 |
| ▸ | ACE | P12821 | 5/20 | 0.62 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19705880 | 1.00 | MME (0.64) | MMEACEMMEL1 | |
| SCHEMBL17968663 | 1.00 | MME (0.64) | MMEACEMMEL1 | |
| SCHEMBL18685531 | 0.93 | MME (0.55) | MMEACEMMEL1 | |
| SCHEMBL19771825 | 0.93 | MME (0.55) | MMEACEMMEL1 | |
| SCHEMBL29598986 | 0.91 | MME (0.53) | MMEACE | |
| SCHEMBL18012933 | 0.89 | MME (0.54) | MMEACEMMEL1 | |
| SCHEMBL19771838 | 0.89 | MME (0.54) | MMEACEMMEL1 | |
| SCHEMBL16241271 | 0.89 | MME (0.79) | MMEACEMMEL1 | |
| SCHEMBL22331066 | 0.89 | MME (0.79) | MMEACEMMEL1 | |
| SCHEMBL19705947 | 0.89 | MME (0.79) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256446-A1 | (2S, 4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-2-ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID AS NEPRILYSIN INHIBITOR | Theravance Biopharma R&D IP, LLC (US) | 2017-12-20 | — | — | EP | claimed |
| WO-2016130650-A1 | (2S, 4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-2-ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID AS NEPRILYSIN INHIBITOR | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-08-18 | — | — | WO | claimed |