Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17969407 | 0.88 | KDM4E (0.38) | HSD17B10KDM4EALDH1A1NPC1TP53 | |
| SCHEMBL17969399 | 0.87 | KDM4E (0.36) | HSD17B10KDM4EALDH1A1NPC1TP53 | |
| SCHEMBL17969302 | 0.84 | KDM4E (0.36) | HSD17B10KDM4EALDH1A1NPC1TP53 | |
| SCHEMBL17969311 | 0.84 | PIK3CD (0.39) | HSD17B10KDM4EALDH1A1NPC1TP53 | |
| SCHEMBL17969313 | 0.83 | FGFR1 (0.38) | HSD17B10KDM4EALDH1A1NPC1TP53 | |
| SCHEMBL17969312 | 0.83 | KDM4E (0.37) | HSD17B10KDM4EALDH1A1NPC1TP53 | |
| SCHEMBL17969372 | 0.82 | MAPT (0.46) | HSD17B10KDM4EALDH1A1NPC1TP53 | |
| SCHEMBL17969377 | 0.80 | KDM4E (0.35) | HSD17B10KDM4EALDH1A1NPC1TP53 | |
| SCHEMBL18595736 | 0.79 | KDM4E (0.36) | HSD17B10KDM4EALDH1A1NPC1TP53 | |
| SCHEMBL18595753 | 0.78 | KDM4E (0.35) | HSD17B10KDM4EALDH1A1NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016130501-A1 | AZA-HETEROARYL COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2016-08-18 | — | — | WO | disclosed |