Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.51 |
| ▸ | TUBB | P07437 | 3/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798566 | 1.00 | KDM4E (0.55) | KDM4ENPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL1796256 | 0.87 | NPC1 (0.68) | KDM4ENPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL1796258 | 0.87 | NPC1 (0.68) | KDM4ENPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL1795683 | 0.86 | KDM4E (0.51) | KDM4ENPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL1795687 | 0.86 | KDM4E (0.51) | KDM4ENPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL28707312 | 0.85 | NPC1 (0.67) | KDM4ENPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL29467913 | 0.85 | NPC1 (0.67) | KDM4ENPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL1799015 | 0.84 | KDM4E (0.51) | KDM4ENPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL1799018 | 0.84 | KDM4E (0.51) | KDM4ENPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL1798200 | 0.82 | NPC1 (0.51) | KDM4ENPC1RAB9AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190364-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-04 | — | — | US | disclosed |
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-04 | — | — | US | disclosed |
| US-7951829-B2 | Benzimidazole modulators of VR1 | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-31 | — | — | US | disclosed |
| US-20070259936-A1 | Benzimidazole Modulators of VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190364-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | VRK1, VRK2, VIL1 | KDM4E 2796/4885NPC1 750/4885RAB9A 3985/4885 |
| US-20070259936-A1 | Benzimidazole Modulators of VR1 | VRK1, VRK2, VIL1 | KDM4E 2796/4885NPC1 750/4885RAB9A 3985/4885 |
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | VRK1, VRK2, VIL1 | KDM4E 2796/4885NPC1 750/4885RAB9A 3985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.