Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795545 | 0.91 | GRM5 (0.43) | GRM5NPC1RAB9A | |
| SCHEMBL1799140 | 0.86 | GRM5 (0.47) | GRM5CYP3A4SLC6A3CYP1A2CYP2C9 | |
| SCHEMBL1793981 | 0.85 | KDM4E (0.40) | GRM5KDM4ENPC1GAARAB9A | |
| SCHEMBL1793317 | 0.85 | NPC1 (0.53) | GRM5KDM4ENPC1GAARAB9A | |
| SCHEMBL1796019 | 0.81 | GRM5 (0.50) | GRM5KDM4ENPC1GAARAB9A | |
| SCHEMBL1794131 | 0.81 | GRM5 (0.50) | GRM5KDM4ENPC1GAARAB9A | |
| SCHEMBL1797370 | 0.77 | GRM5 (0.48) | GRM5 | |
| SCHEMBL1793266 | 0.76 | NPC1 (0.50) | GRM5KDM4ENPC1GAARAB9A | |
| SCHEMBL1796066 | 0.76 | GRM5 (0.51) | GRM5KDM4E | |
| SCHEMBL1795492 | 0.76 | POLQ (0.44) | GRM5NPC1RAB9ACYP3A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |