Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
| ▸ | IL2 | P60568 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.33 |
| ▸ | DLK1 | P80370 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798767 | 1.00 | MAPK8 (0.51) | MAPK8MAPK9MAPK10MAP4K1IL2 | |
| SCHEMBL1798305 | 0.95 | MAPK8 (0.52) | MAPK8MAPK9MAPK10MAP4K1IL2 | |
| SCHEMBL1798301 | 0.95 | MAPK8 (0.52) | MAPK8MAPK9MAPK10MAP4K1IL2 | |
| SCHEMBL1798565 | 0.93 | MAPK8 (0.62) | MAPK8MAPK9MAPK10MAP4K1IL2 | |
| SCHEMBL1798563 | 0.93 | MAPK8 (0.62) | MAPK8MAPK9MAPK10MAP4K1IL2 | |
| SCHEMBL1801507 | 0.90 | MAPK8 (0.64) | MAPK8MAPK9MAPK10MAP4K1IL2 | |
| SCHEMBL1801506 | 0.90 | MAPK8 (0.64) | MAPK8MAPK9MAPK10MAP4K1IL2 | |
| SCHEMBL1797497 | 0.89 | MAPK8 (0.53) | MAPK8MAPK9MAPK10MAP4K1IL2 | |
| SCHEMBL1797495 | 0.89 | MAPK8 (0.53) | MAPK8MAPK9MAPK10MAP4K1IL2 | |
| SCHEMBL8172108 | 0.89 | MAPK8 (0.53) | MAPK8MAPK9MAPK10MAP4K1IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951802-B2 | Use of 7-azaindoles in the inhibition of c-Jun N-terminal kinase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| US-20100069358-A1 | USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069358-A1 | USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | MAPK7, MAPKAPK5, MAPK13 | MAPK8 33/4885MAPK9 27/4885MAPK10 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.