Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10023784 | 0.95 | KDM4E (0.43) | KDM4EL3MBTL1ATMMAPTTP53 | |
| SCHEMBL20821423 | 0.92 | KDM4E (0.46) | KDM4EL3MBTL1ATMMAPTTP53 | |
| SCHEMBL17993484 | 0.91 | KDM4E (0.49) | KDM4EL3MBTL1ATMMAPTTP53 | |
| SCHEMBL10023330 | 0.88 | KDM4E (0.47) | KDM4EL3MBTL1ATMMAPTTP53 | |
| SCHEMBL20821408 | 0.88 | KDM4E (0.45) | KDM4EL3MBTL1ATMMAPTTP53 | |
| SCHEMBL10023443 | 0.87 | KDM4E (0.46) | KDM4EL3MBTL1ATMMAPTTP53 | |
| SCHEMBL10023092 | 0.87 | KDM4E (0.46) | KDM4EL3MBTL1ATMMAPTTP53 | |
| SCHEMBL10023072 | 0.86 | KDM4E (0.48) | KDM4EL3MBTL1ATMMAPTTP53 | |
| SCHEMBL10023708 | 0.86 | KDM4E (0.48) | KDM4EL3MBTL1ATMMAPTTP53 | |
| SCHEMBL10023830 | 0.86 | KDM4E (0.41) | KDM4EL3MBTL1ATMMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054498-B1 | BISIMIDAZODIAZOCINES | IDEMITSU KOSAN CO (JP) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016125110-A1 | BISIMIDAZOLODIAZOCINES | IDEMITSU KOSAN CO., LTD. (JP) | 2016-08-11 | — | — | WO | disclosed |
| EP-3054498-A1 | Bisimidazodiazocines | Idemitsu Kosan Co., Ltd. (JP) | 2016-08-10 | — | — | EP | disclosed |