Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL18009034 | 1.00 | MAPT (0.39) | MAPTKCNH2EPHX1NR1I2CA2 | |
| Lithium Ion SCHEMBL18009054 | 1.00 | MAPT (0.39) | MAPTKCNH2EPHX1NR1I2CA2 | |
| Lithium Ion SCHEMBL18008821 | 1.00 | MAPT (0.39) | MAPTKCNH2EPHX1NR1I2CA2 | |
| Lithium Ion SCHEMBL18008724 | 1.00 | MAPT (0.39) | MAPTKCNH2EPHX1NR1I2CA2 | |
| Lithium Ion SCHEMBL18008905 | 0.98 | MAPT (0.36) | MAPTKCNH2EPHX1NR1I2CA2 | |
| Potassium Ion SCHEMBL18008287 | 0.96 | MAPT (0.39) | MAPTKCNH2EPHX1NR1I2CA2 | |
| Potassium Ion SCHEMBL18008635 | 0.96 | MAPT (0.39) | MAPTKCNH2EPHX1NR1I2CA2 | |
| SCHEMBL18007924 | 0.96 | NR1I2 (0.40) | MAPTKCNH2EPHX1NR1I2CA2 | |
| SCHEMBL18008762 | 0.96 | NR1I2 (0.40) | MAPTKCNH2EPHX1NR1I2CA2 | |
| SCHEMBL18008761 | 0.96 | NR1I2 (0.40) | MAPTKCNH2EPHX1NR1I2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3367088-A1 | ELECTROCHEMICAL GAS SENSOR AND ELECTROLYTE FOR AN ELECTROCHEMICAL GAS SENSOR | Dräger Safety AG & Co. KGaA (DE) | 2018-08-29 | — | — | EP | disclosed |
| EP-3259583-A1 | ELECTROCHEMICAL GAS SENSOR AND ELECTROLYTE FOR AN ELECTROCHEMICAL GAS SENSOR | Dräger Safety AG & Co. KGaA (DE) | 2017-12-27 | — | — | EP | disclosed |
| WO-2016131549-A1 | ELECTROCHEMICAL GAS SENSOR AND ELECTROLYTE FOR AN ELECTROCHEMICAL GAS SENSOR | Dräger Safety AG & Co. KGaA (DE) | 2016-08-25 | — | — | WO | disclosed |