Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MASP2 | O00187 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18009452 | 0.83 | DPP4 (0.45) | CTSCMC4RDPP4HPGDALDH1A1 | |
| SCHEMBL18009199 | 0.81 | CTSC (0.36) | CTSCDPP4 | |
| SCHEMBL1162981 | 0.80 | MC4R (0.51) | CTSCMC4RDPP4CACNA1GHTR2C | |
| SCHEMBL18009191 | 0.78 | CTSC (0.40) | CTSCALDH1A1MAPT | |
| SCHEMBL18009200 | 0.78 | CTSC (0.34) | CTSCHPGDALDH1A1MAPTMEN1 | |
| SCHEMBL18009198 | 0.77 | HCAR2 (0.38) | CTSCL3MBTL1 | |
| SCHEMBL18009286 | 0.76 | HCAR2 (0.41) | CTSCTSHR | |
| SCHEMBL25111799 | 0.76 | CTSC (0.59) | CTSCMC4RDPP4CACNA1GHTR2C | |
| SCHEMBL18576456 | 0.76 | CTSC (0.59) | CTSCMC4RDPP4CACNA1GHTR2C | |
| SCHEMBL1162854 | 0.74 | MC4R (0.59) | CTSCMC4RDPP4CACNA1GHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016127186-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | NGUYEN MARK QUANG (US) | 2016-08-11 | — | — | WO | disclosed |