Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 11/20 | 0.59 |
| ▸ | BTK | Q06187 | 6/20 | 0.59 |
| ▸ | MET | P08581 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 6/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18011892 | 0.91 | SYK (0.66) | SYKEGFRBTKJAK3MAPK8 | |
| SCHEMBL14769149 | 0.87 | BTK (0.64) | SYKEGFRBTKMETJAK3 | |
| SCHEMBL13498136 | 0.86 | EGFR (0.59) | SYKEGFRBTKITK | |
| SCHEMBL14769279 | 0.86 | EGFR (0.69) | SYKEGFRBTKJAK3ITK | |
| SCHEMBL18012019 | 0.86 | SYK (0.60) | SYKEGFRBTKJAK3ITK | |
| SCHEMBL12519750 | 0.85 | BTK (0.77) | SYKEGFRBTKJAK3ITK | |
| SCHEMBL14679200 | 0.84 | SYK (0.60) | SYKEGFRBTKMAPK8MAPK9 | |
| SCHEMBL13074512 | 0.84 | SYK (0.60) | SYKEGFRBTKMETMAPK8 | |
| SCHEMBL13166506 | 0.83 | SYK (0.67) | SYKEGFRBTKJAK3ITK | |
| SCHEMBL18357348 | 0.83 | EGFR (0.59) | SYKEGFRBTKJAK3MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016124160-A1 | PYRIMIDOPYRIMIDINEDIONE DERIVATIVES AS EGFR INHIBITORS AND APPLICATION THEREOF | 华东理工大学 | 2016-08-11 | — | — | WO | disclosed |