Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.63 |
| ▸ | KDR | P35968 | 15/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 11/20 | 0.62 |
| ▸ | EPHB4 | P54760 | 11/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.62 |
| ▸ | FLT1 | P17948 | 10/20 | 0.62 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | EPHA4 | P54764 | 2/20 | 0.62 |
| ▸ | BTK | Q06187 | 2/20 | 0.62 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | YES1 | P07947 | 1/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18012086 | 1.00 | EGFR (0.63) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL17967489 | 0.95 | EGFR (0.57) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL18012077 | 0.93 | KDR (0.66) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL19885273 | 0.93 | KDR (0.61) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL19885266 | 0.93 | KDR (0.61) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL18012088 | 0.93 | KDR (0.66) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL18012084 | 0.89 | ERBB2 (0.70) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL19885304 | 0.89 | KDR (0.57) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL19100062 | 0.88 | EGFR (0.53) | EGFRKDREPHA2EPHB4ERBB2 | |
| SCHEMBL18012884 | 0.88 | EGFR (0.53) | EGFRKDREPHA2EPHB4ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180050993-A1 | NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS | TRILLIUM THERAPEUTICS INC. (CA) | 2018-02-22 | — | — | US | disclosed |
| US-20180050993-A1 | NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS | TRILLIUM THERAPEUTICS INC. (CA) | 2018-02-22 | — | — | US | disclosed |
| US-20180050993-A1 | NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS | TRILLIUM THERAPEUTICS INC. (CA) | 2018-02-22 | — | — | US | disclosed |
| WO-2016123706-A1 | NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS | TRILLIUM THERAPEUTICS INC. (CA) | 2016-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180050993-A1 | NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS | EGFR, ERBB2, ERBB4 | EGFR 1/4885KDR 339/4885EPHA2 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.