Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rupatadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 18/20 | 0.86 |
| ▸ | PTAFR known ✓ | P25105 | 2/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | FNTA | P49354 | 3/20 | 0.60 |
| ▸ | FNTB | P49356 | 3/20 | 0.60 |
| ▸ | SLC6A15 | Q9H2J7 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rupatadine SCHEMBL19474963 | 1.00 | HRH1 (0.86) | HRH1PTAFRKCNH2FNTAFNTB | |
| Rupatadine SCHEMBL31116805 | 1.00 | HRH1 (0.86) | HRH1PTAFRKCNH2FNTAFNTB | |
| Rupatadine SCHEMBL29101069 | 1.00 | HRH1 (0.86) | HRH1PTAFRKCNH2FNTAFNTB | |
| Rupatadine SCHEMBL180512 | 1.00 | HRH1 (0.86) | HRH1PTAFRKCNH2FNTAFNTB | |
| Rupatadine SCHEMBL29602857 | 1.00 | HRH1 (0.86) | HRH1PTAFRKCNH2FNTAFNTB | |
| Rupatadine SCHEMBL27743704 | 0.98 | HRH1 (0.82) | HRH1PTAFRKCNH2FNTAFNTB | |
| Rupatadine SCHEMBL29400290 | 0.93 | HRH1 (1.00) | HRH1PTAFRKCNH2FNTAFNTB | |
| Rupatadine SCHEMBL27703 | 0.93 | HRH1 (1.00) | HRH1PTAFRKCNH2FNTAFNTB | |
| Rupatadine SCHEMBL30730975 | 0.93 | HRH1 (1.00) | HRH1PTAFRKCNH2FNTAFNTB | |
| Rupatadine SCHEMBL28585002 | 0.92 | HRH1 (0.98) | HRH1PTAFRKCNH2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 586 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4633613-A1 | PHARMACEUTICAL COMPOSITION COMPRISING RUPATADINE AND MONTELUKAST | NOUCOR HEALTH S.A. (ES) | 2025-10-22 | — | — | EP | claimed |
| CN-120022237-A | Rupatadine fumarate oral liquid and preparation method thereof | 广州市桐晖药业有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-119915918-A | Separation, qualitative and quantitative detection method for related substances in rupatadine fumarate | 重庆华邦制药有限公司 | 2025-05-02 | — | — | CN | claimed |
| CN-119798217-A | Rupatadine fumarate starting material SM1And method for separating and measuring impurities thereof | 重庆华邦制药有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-119707934-A | Preparation method of rupatadine fumarate and intermediate compound | 潍坊亚星化学股份有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-119688848-A | HPLC separation determination of rupatadine fumarate Z3And method for impurity thereof | 重庆华邦制药有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-119164844-A | Rupatadine fumarate raw material particle size distribution detection method | 扬子江药业集团江苏紫龙药业有限公司 | 2024-12-20 | — | — | CN | claimed |
| CN-118837469-A | Analysis and detection method and application of genotoxic impurities in rupatadine fumarate | 哈尔滨珍宝制药有限公司 | 2024-10-25 | — | — | CN | claimed |
| CN-118566392-A | Rupatadine fumarate impurity detection method | 浙江兄弟药业有限公司 | 2024-08-30 | — | — | CN | claimed |
| EP-3397285-B1 | TABLET FORMULATIONS OF MONTELUKAST SODIUM AND RUPATADINE FUMARATE | SANOVEL ILAC SANAYI VE TICARET AS (TR) | 2024-08-14 | — | — | EP | claimed |
| CN-102652740-A | Rupatadine fumarate dry powder inhalant and preparation method thereof | DONGGUAN DAXIN BIOLOG ENGINEERING CO LTD | 2012-09-05 | — | — | CN | claimed |
| CN-101926762-B | Rupatadine fumarate eye drops and preparation method thereof | HYDRON CONTACT LENS CO LTD | 2012-07-18 | — | — | CN | claimed |
| WO-2012001093-A2 | LIQUID FORMULATIONS OF RUPATADINE FUMARATE | J. URIACH Y COMPAÑÍA, S.A. (ES) | 2012-01-05 | — | — | WO | claimed |
| EP-2402012-A2 | Liquid formulations of rupatadine fumarate | J. Uriach y Compania S.A. (ES) | 2012-01-04 | — | — | EP | claimed |
| CN-102030739-A | Method for salifying or recrystallization of rupatadine fumarate | NANJING VARSAL MEDICINE TECHNOLOGY DEV CO LTD | 2011-04-27 | — | — | CN | claimed |
| CN-101926762-A | Rupatadine fumarate eye drops and preparation method thereof | HYDRON CONTACT LENS CO LTD | 2010-12-29 | — | — | CN | claimed |
| CN-101683527-A | Compound preparation for treating cold and preparation method thereof | BEIJNG SHKB PHARMACEUTICAL CO | 2010-03-31 | — | — | CN | claimed |
| CN-101590050-A | Medicine of a kind of treatment of allergic rhinitis and preparation method thereof | JIAOZUO XIANDA TRADE CO LTD (CN) | 2009-12-02 | — | — | CN | claimed |
| CN-101324551-A | Quality control method of rupatadine fumarate | GUANGDONG KANGHONG PHARMACEUTI (CN) | 2008-12-17 | — | — | CN | claimed |
| WO-2006114676-A2 | A PROCESS FOR THE PREPARATION OF RUPATADINE | CADILA PHARMACEUTICALS LIMITED (IN) | 2006-11-02 | — | — | WO | claimed |