Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methylpyrrolidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.77 |
| ▸ | BRD2 | P25440 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | INMT | O95050 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylpyrrolidone SCHEMBL28608007 | 0.98 | BRD4 (0.74) | BRD4BRD2LMNAALDH1A1KMT2A | |
| Methylpyrrolidone SCHEMBL28884394 | 0.98 | BRD4 (0.74) | BRD4BRD2LMNAALDH1A1KMT2A | |
| Methylpyrrolidone SCHEMBL10701586 | 0.93 | BRD4 (0.81) | BRD4BRD2LMNAALDH1A1KMT2A | |
| Methylpyrrolidone SCHEMBL2243830 | 0.93 | BRD4 (0.81) | BRD4BRD2LMNAALDH1A1KMT2A | |
| Methylpyrrolidone SCHEMBL28866005 | 0.91 | BRD4 (0.77) | BRD4BRD2LMNAALDH1A1KMT2A | |
| Methylpyrrolidone SCHEMBL28525083 | 0.91 | BRD4 (0.77) | BRD4BRD2LMNAALDH1A1KMT2A | |
| Methylpyrrolidone SCHEMBL6251574 | 0.89 | BRD4 (0.74) | BRD4BRD2LMNAALDH1A1KMT2A | |
| Methylpyrrolidone SCHEMBL1368701 | 0.88 | — | — | |
| Methylpyrrolidone SCHEMBL5423326 | 0.88 | — | — | |
| Methylpyrrolidone SCHEMBL8055062 | 0.88 | BRD4 (1.00) | BRD4BRD2LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1121273-C | Double metal cyanide catalysts contg. cyclic, bidentate complexing agent | BAYER ANTWERPEN NV (BE) | 2003-09-17 | — | — | CN | claimed |
| US-6488730-B2 | Polishing composition | CHEIL INDUSTRIES, INC. (KR) | 2002-12-03 | — | — | US | claimed |
| US-20020022369-A1 | Polishing composition | CHEIL INDUSTRIES, INC. (KR) | 2002-02-21 | — | — | US | claimed |
| CN-1309587-A | Double metal cyanide catalysts contg. cyclic, bidentate complexing agent | BAYER ANTWERPEN NV (BE) | 2001-08-22 | — | — | CN | claimed |
| CN-118459387-A | Piracetam preparation method | 湖南赛隆药业(长沙)有限公司 | 2024-08-09 | — | — | CN | disclosed |
| CN-117999475-A | Electrochemical gas sensor and electrolyte for electrochemical gas sensor | 德尔格安全股份两合公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-115845812-B | Preparation method and application of magnetic lignin adsorption material | 大连工业大学 | 2024-05-03 | — | — | CN | disclosed |
| CN-111247182-B | Block copolymer, dispersant, coloring composition, and color filter | 大塚化学株式会社 | 2023-08-22 | — | — | CN | disclosed |
| CN-116574045-A | Preparation method of piracetam raw material | 河北龙海药业有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-115845812-A | Preparation method and application of magnetic lignin adsorption material | 大连工业大学 | 2023-03-28 | — | — | CN | disclosed |
| CN-111094373-B | Two-component system for elastomeric coatings | 科思创德国股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-111971116-B | Dispersant composition, coloring composition and color filter | 大塚化学株式会社 | 2022-06-28 | — | — | CN | disclosed |
| EP-0541654-A1 | BOMBESIN ANTAGONISTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-05-19 | — | — | EP | disclosed |
| EP-0522082-A1 | MULTI-FUNCTIONAL PHARMACEUTICAL COMPOUNDS AND METHODS OF USE. | GLASKY ALVIN J (US) | 1993-01-13 | — | — | EP | disclosed |
| US-5091432-A | Synergistic | SPECTRUM PHARMACEUTICALS, INC. | 1992-02-25 | — | — | US | disclosed |
| WO-1992002545-A1 | BOMBESIN ANTAGONISTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-02-20 | — | — | WO | disclosed |
| WO-1991014434-A1 | MULTI-FUNCTIONAL PHARMACEUTICAL COMPOUNDS AND METHODS OF USE | GLASKY ALVIN J (US) | 1991-10-03 | — | — | WO | disclosed |
| EP-0427636-A2 | 4-Acylaminopyridine derivatives | Mitsubishi Chemical Corporation (JP) | 1991-05-15 | — | — | EP | disclosed |
| US-4985430-A | ALZHEIMER*S DISEASE | MITSUBISHI KASEI CORPORATION (JP) | 1991-01-15 | — | — | US | disclosed |
| EP-0319429-A2 | 9-Acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient | MITSUBISHI KASEI CORPORATION (JP) | 1989-06-07 | — | — | EP | disclosed |