Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.52 |
| ▸ | FLT1 | P17948 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 11/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | KIF5B | P33176 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | FLT4 | P35916 | 3/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.48 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18012884 | 0.93 | EGFR (0.53) | KDRFLT1EGFRRETKIF5B | |
| SCHEMBL17967491 | 0.92 | KDR (0.61) | KDRFLT1EGFRRETKIF5B | |
| SCHEMBL18012088 | 0.88 | KDR (0.66) | KDRFLT1EGFRRETKIF5B | |
| SCHEMBL18012077 | 0.88 | KDR (0.66) | KDRFLT1EGFRRETKIF5B | |
| SCHEMBL18012880 | 0.87 | ERBB2 (0.55) | KDREGFRRETKIF5BERBB2 | |
| SCHEMBL19126094 | 0.87 | KDR (0.52) | KDRFLT1EGFRRETKIF5B | |
| SCHEMBL17967489 | 0.84 | EGFR (0.57) | KDRFLT1EGFRRETFGFR1 | |
| SCHEMBL18012883 | 0.84 | EGFR (0.71) | KDREGFRFLT4ERBB2EPHB4 | |
| SCHEMBL19125349 | 0.83 | KDR (0.49) | KDRFLT1EGFRFGFR1FLT4 | |
| SCHEMBL18013036 | 0.82 | ERBB2 (0.57) | KDRFLT1EGFRRETFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123706-A1 | NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS | TRILLIUM THERAPEUTICS INC. (CA) | 2016-08-11 | — | — | WO | disclosed |