SCHEMBL18013307

SCHEMBL18013307

CS(=O)(=O)NC(=O)c1cc(Cl)c(C(=O)O)cc1F

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.60
SCN5A Q14524 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL364803 0.86 SCN9A (0.60) SCN9A
SCHEMBL363340 0.83 SCN9A (0.58) SCN9A
SCHEMBL364516 0.82 SCN9A (0.58) SCN9ASCN5A
SCHEMBL16618519 0.82 SCN9A (0.56) SCN9A
SCHEMBL366524 0.78 SCN9A (0.65) SCN9ASCN5A
SCHEMBL365435 0.78 SCN9A (0.55) SCN9ASCN5A
SCHEMBL364677 0.78 SCN9A (0.55) SCN9ASCN5A
SCHEMBL15537021 0.76 SCN9A (0.60) SCN9ASCN5A
SCHEMBL16618531 0.76 SCN9A (0.53) SCN9ASCN5A
SCHEMBL16389215 0.76 SCN9A (1.00) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020199757-A1 SULFONYLBENZAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF 上海海雁医药科技有限公司 2020-10-08 WO disclosed
WO-2016124139-A1 HETEROCYCLIC-SUBSTITUTED N-SULFONYLBENZAMIDE DERIVATIVES, PREPARATION METHOD FOR DERIVATIVES, AND PHARMACEUTICAL USE OF DERIVATIVES 上海海雁医药科技有限公司 2016-08-11 WO disclosed