Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015123 | 1.00 | ALOX5AP (0.44) | ALOX5APFEN1NR1H2KDM4EPKM | |
| SCHEMBL18015132 | 1.00 | ALOX5AP (0.44) | ALOX5APFEN1NR1H2KDM4EPKM | |
| SCHEMBL18015126 | 0.92 | HPGD (0.48) | KDM4EPKMHPGDRECQLEPHX1 | |
| SCHEMBL18015114 | 0.88 | NR1H2 (0.51) | ALOX5APFEN1NR1H2HPGDMEN1 | |
| SCHEMBL26314855 | 0.87 | NR1H2 (0.44) | ALOX5APFEN1NR1H2KDM4EPKM | |
| SCHEMBL3713220 | 0.86 | NR1H2 (0.43) | ALOX5APFEN1NR1H2KDM4EPKM | |
| SCHEMBL3713222 | 0.85 | NR1H2 (0.43) | ALOX5APFEN1NR1H2KDM4EPKM | |
| SCHEMBL25315068 | 0.84 | NR1H2 (0.47) | ALOX5APFEN1NR1H2KDM4EPKM | |
| SCHEMBL25311356 | 0.84 | NR1H2 (0.47) | ALOX5APFEN1NR1H2KDM4EPKM | |
| SCHEMBL16892198 | 0.84 | NR1H2 (0.49) | ALOX5APFEN1NR1H2KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180016227-A1 | PROCESS FOR THE SYNTHESIS OF DIFLUOROMETHYL ETHER-BASED COMPOUNDS | TRILLIUM THERAPEUTICS INC. (CA) | 2018-01-18 | — | — | US | disclosed |
| WO-2016123707-A1 | PROCESS FOR THE SYNTHESIS OF DIFLUOROMETHYL ETHER-BASED COMPOUNDS | TRILLIUM THERAPEUTICS INC. (CA) | 2016-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180016227-A1 | PROCESS FOR THE SYNTHESIS OF DIFLUOROMETHYL ETHER-BASED COMPOUNDS | CYP2F1, CYP2E1, PAH | ALOX5AP 1273/4885FEN1 4052/4885NR1H2 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.