SCHEMBL18015192

SCHEMBL18015192

CCOc1ccc(-c2ccc(C3=CCC(C)OC3)cc2)c(F)c1F

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FGFR2 P21802 2/20 0.34
FGFR1 P11362 1/20 0.34
GRM2 Q14416 3/20 0.33
FPR2 P25090 3/20 0.32
FFAR4 Q5NUL3 1/20 0.31
TP53 P04637 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
KDM1A O60341 2/20 0.30
PTPRC P08575 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18015236 0.90 KDM1A (0.33) FGFR2FGFR1FPR2KDM1A
SCHEMBL18015194 0.89 KDM1A (0.32) FGFR2FGFR1FPR2KDM1A
SCHEMBL18007074 0.84 FGFR2 (0.32) FGFR2FGFR1FPR2FFAR4
SCHEMBL18015200 0.82 KDM1A (0.42) FGFR2GRM2TP53POLBMAPT
SCHEMBL18006910 0.82 FGFR1 (0.31) FGFR2FGFR1FFAR4
SCHEMBL18006634 0.81
SCHEMBL18015204 0.79 FGFR2 (0.32) FGFR2FGFR1GRM2KDM1A
SCHEMBL18015179 0.79
SCHEMBL13000414 0.79 FGFR2 (0.33) FGFR2FGFR1FPR2FFAR4KDM1A
SCHEMBL18007034 0.79 GRIN1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160230094-A1 LIQUID CRYSTAL COMPOUND HAVING A 3,6-DIHYDRO-2H-PYRAN RING, NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2016-08-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160230094-A1 LIQUID CRYSTAL COMPOUND HAVING A 3,6-DIHYDRO-2H-PYRAN RING, NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE DRD1, ZKSCAN2, ZRANB2 FGFR2 1144/4885FGFR1 1964/4885GRM2 1116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.