Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.55 |
| ▸ | PDE4A | P27815 | 11/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015959 | 0.91 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DMAOA | |
| SCHEMBL18015971 | 0.89 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL18015958 | 0.88 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL18015949 | 0.87 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2530561 | 0.86 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL18015955 | 0.86 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2527604 | 0.85 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL19622227 | 0.85 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE1A | |
| SCHEMBL2527722 | 0.83 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL18015962 | 0.83 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4DCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246034-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | Anacor Pharmaceuticals, Inc. (US) | 2017-11-22 | — | — | EP | disclosed |
| US-9416146-B2 | Boron-containing small molecules as anti-inflammatory agents | ANACOR PHARMACEUTICALS, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416146-B2 | Boron-containing small molecules as anti-inflammatory agents | ANACOR PHARMACEUTICALS, INC. (US) | 2016-08-16 | — | — | US | disclosed |