Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | AMD1 | P17707 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800449 | 0.88 | RXFP1 (0.61) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1799458 | 0.84 | PI4KA (0.66) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1800390 | 0.83 | RXFP1 (0.57) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL18314858 | 0.83 | PI4KA (0.70) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1799357 | 0.83 | RXFP1 (0.57) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1945010 | 0.83 | RXFP1 (0.49) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1801717 | 0.83 | RXFP1 (0.49) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL5319771 | 0.83 | RXFP1 (0.56) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1794414 | 0.83 | RXFP1 (0.56) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL24450944 | 0.81 | RXFP1 (0.56) | RXFP1PI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951810-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |