Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 19/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801959 | 0.92 | TRPV1 (0.70) | TRPV1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL2933393 | 0.92 | TRPV1 (0.70) | TRPV1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL1794735 | 0.86 | TRPV1 (0.75) | TRPV1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL1797964 | 0.83 | TRPV1 (0.83) | TRPV1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL1797962 | 0.83 | TRPV1 (0.83) | TRPV1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL1800920 | 0.82 | TRPV1 (0.65) | TRPV1 | |
| SCHEMBL1800502 | 0.82 | TRPV1 (0.68) | TRPV1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL1800499 | 0.82 | TRPV1 (0.68) | TRPV1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL1798183 | 0.82 | TRPV1 (0.62) | TRPV1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL1798187 | 0.82 | TRPV1 (0.62) | TRPV1KDM4EMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951829-B2 | Benzimidazole modulators of VR1 | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-31 | — | — | US | claimed |