Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.72 |
| ▸ | JAK1 | P23458 | 8/20 | 0.72 |
| ▸ | TYK2 | P29597 | 3/20 | 0.72 |
| ▸ | JAK3 | P52333 | 3/20 | 0.72 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29464036 | 0.84 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2237596 | 0.84 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2185451 | 0.83 | JAK1 (0.65) | JAK2JAK1TYK2JAK3EGLN2 | |
| SCHEMBL29883411 | 0.78 | JAK2 (0.62) | JAK2JAK1TYK2JAK3EGLN2 | |
| Cyclopropane SCHEMBL15654165 | 0.73 | TYK2 (0.64) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL7977778 | 0.73 | JAK2 (0.64) | JAK2JAK1TYK2JAK3EGLN2 | |
| Cyclopropane SCHEMBL15654069 | 0.72 | JAK2 (0.61) | JAK2JAK1TYK2JAK3EGLN2 | |
| Cyclopropane SCHEMBL15653676 | 0.72 | JAK1 (0.61) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2235843 | 0.72 | TYK2 (0.81) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2237985 | 0.71 | JAK2 (0.79) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9415037-B2 | Compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS NV (BE) | 2016-08-16 | — | — | US | disclosed |