SCHEMBL18019795

SCHEMBL18019795

COc1ccccc1C[C@@H]1CCCN1

nearest known ligand 0.64

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 4/20 0.64
CHRNA3 P32297 4/20 0.64
TACR1 P25103 4/20 0.52
HTR6 P50406 5/20 0.51
POLB P06746 1/20 0.49
CHRNB2 P17787 1/20 0.47
CHRNA4 P43681 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18019797 1.00 CHRNB4 (0.64) CHRNB4CHRNA3TACR1HTR6POLB
SCHEMBL13877462 1.00 CHRNB4 (0.64) CHRNB4CHRNA3TACR1HTR6POLB
Hydrochloric Acid SCHEMBL3636932 0.98 CHRNB4 (0.62) CHRNB4CHRNA3TACR1HTR6POLB
SCHEMBL18019873 0.95 CHRNB4 (0.58) CHRNB4CHRNA3TACR1HTR6POLB
SCHEMBL18019869 0.95 CHRNB4 (0.58) CHRNB4CHRNA3TACR1HTR6POLB
SCHEMBL17979768 0.95 CHRNB4 (0.58) CHRNB4CHRNA3TACR1HTR6POLB
SCHEMBL11471256 0.94 CHRNB4 (0.57) CHRNB4CHRNA3TACR1HTR6POLB
SCHEMBL23477672 0.87 CHRNB4 (0.53) CHRNB4CHRNA3TACR1HTR6
SCHEMBL30475084 0.87 CHRNB4 (0.53) CHRNB4CHRNA3TACR1HTR6
SCHEMBL8792312 0.85 CHRNB4 (0.61) CHRNB4CHRNA3TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021068530-A1 Z-TYPE SOLANONE, PREPARATION METHOD THEREFOR, AND USE 云南中烟工业有限责任公司 2021-04-15 WO claimed
WO-2021068530-A1 Z-TYPE SOLANONE, PREPARATION METHOD THEREFOR, AND USE 云南中烟工业有限责任公司 2021-04-15 WO disclosed
WO-2016128140-A1 PYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER MERCK PATENT GMBH (DE) 2016-08-18 WO disclosed