Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | PDE5A | O76074 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20273385 | 0.96 | ABCG2 (0.59) | ABCG2ABCB1PDE5AMAPTMEN1 | |
| SCHEMBL18022953 | 0.93 | ABCG2 (0.64) | ABCG2ABCB1MAPTMEN1KMT2A | |
| SCHEMBL14474886 | 0.90 | ABCG2 (0.60) | ABCG2ABCB1PDE5AMAPTMEN1 | |
| SCHEMBL18022946 | 0.88 | ABCG2 (0.60) | ABCG2ABCB1PDE5AMAPTMEN1 | |
| SCHEMBL20273476 | 0.87 | MEN1 (0.62) | ABCG2PDE5AMAPTMEN1KMT2A | |
| SCHEMBL14727301 | 0.87 | ABCG2 (0.61) | ABCG2ABCB1PDE5AMAPTMEN1 | |
| SCHEMBL14727294 | 0.86 | ABCG2 (0.60) | ABCG2ABCB1PDE5AMAPTMEN1 | |
| SCHEMBL14727346 | 0.85 | ABCG2 (0.79) | ABCG2ABCB1PDE5AMAPTMEN1 | |
| SCHEMBL14727311 | 0.85 | ABCG2 (0.64) | ABCG2ABCB1PDE5AMAPTMEN1 | |
| SCHEMBL20273431 | 0.85 | ABCG2 (0.58) | ABCG2ABCB1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3056207-B1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMA CO LTD (JP) | 2018-06-20 | — | — | EP | disclosed |
| EP-3056207-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | Otsuka Pharmaceutical Co., Ltd. (JP) | 2016-08-17 | — | — | EP | disclosed |