Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 8/20 | 0.55 |
| ▸ | PDE5A | O76074 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14727833 | 0.89 | ABCG2 (0.56) | GBA1KMT2ACYP1A2CYP3A4TSHR | |
| SCHEMBL14727836 | 0.86 | ABCG2 (0.57) | GBA1KMT2ACYP1A2CYP3A4TSHR | |
| SCHEMBL14727828 | 0.83 | MAPT (0.57) | GBA1KMT2ACYP1A2CYP3A4TSHR | |
| SCHEMBL14727977 | 0.79 | CYP1A2 (0.65) | GBA1PDE5AKMT2ACYP1A2CYP3A4 | |
| SCHEMBL14475102 | 0.79 | MAPT (0.58) | GBA1KMT2ACYP1A2CYP3A4TSHR | |
| SCHEMBL14474073 | 0.79 | PDE5A (0.56) | GBA1PDE5AKMT2ACYP1A2CYP3A4 | |
| SCHEMBL14474117 | 0.79 | ABCG2 (0.57) | GBA1KMT2ACYP1A2CYP3A4TSHR | |
| SCHEMBL14727887 | 0.78 | MAPT (0.61) | GBA1PDE5AKMT2ACYP1A2CYP3A4 | |
| SCHEMBL14358791 | 0.77 | GBA1 (0.60) | GBA1PDE5ACYP1A2CYP3A4TSHR | |
| SCHEMBL14475079 | 0.77 | MAPT (0.56) | GBA1KMT2ACYP1A2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3056207-A1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | Otsuka Pharmaceutical Co., Ltd. (JP) | 2016-08-17 | — | — | EP | disclosed |