Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29374646 | 1.00 | SOAT1 (0.50) | SOAT1MEN1POLBKMT2AATM | |
| SCHEMBL12244568 | 0.96 | SOAT1 (0.48) | SOAT1MEN1POLBKMT2AATM | |
| SCHEMBL12654166 | 0.81 | SOAT1 (0.53) | SOAT1 | |
| SCHEMBL1801445 | 0.81 | SOAT1 (0.38) | SOAT1 | |
| SCHEMBL12620845 | 0.81 | SOAT1 (0.38) | SOAT1 | |
| SCHEMBL12620847 | 0.80 | SOAT1 (0.43) | SOAT1 | |
| SCHEMBL1808525 | 0.80 | SOAT1 (0.43) | SOAT1 | |
| SCHEMBL12620818 | 0.80 | SOAT1 (0.41) | SOAT1 | |
| SCHEMBL8619226 | 0.77 | SOAT1 (0.41) | SOAT1 | |
| SCHEMBL12620807 | 0.77 | SOAT1 (0.38) | SOAT1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958970-A | ENZYME INHIBITORS OF ACETYLCHOLINESTERASE (ACHE) AND ACYL-COA:CHOLESTEROL ACYLTRANSFERASE (ACAT); USED IN THE TREATMENT OF ALZHEIMER'S DISEASE, ATHEROSCLEROSIS AND HYPERCHOLESTEROLEMIA | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1999-09-28 | — | — | US | claimed |
| WO-1998039010-A1 | TRICYCLIC AND TETRACYCLIC PYRONES | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1998-09-11 | — | — | WO | claimed |
| US-7935726-B1 | Tricyclic pyrones | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-05-03 | — | — | US | disclosed |
| US-6916824-B1 | Methods of treating cataracts and diabetic retinopathy with tricyclic pyrones | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-07-12 | — | — | US | disclosed |
| US-6384045-B1 | TREATMENT OF ALZHEIMER'S DISEASE AND ANTICANCER AGENTS | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION | 2002-05-07 | — | — | US | disclosed |
| US-5958970-A | ENZYME INHIBITORS OF ACETYLCHOLINESTERASE (ACHE) AND ACYL-COA:CHOLESTEROL ACYLTRANSFERASE (ACAT); USED IN THE TREATMENT OF ALZHEIMER'S DISEASE, ATHEROSCLEROSIS AND HYPERCHOLESTEROLEMIA | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1999-09-28 | — | — | US | disclosed |
| WO-1998039010-A1 | TRICYCLIC AND TETRACYCLIC PYRONES | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1998-09-11 | — | — | WO | disclosed |